Circular Dichroism (CD) Circular Dichroism (CD)

CD is a powerful spectroscopic technique for rapid estimation of secondary structure of recombinant and native proteins as well as synthetic peptides. In addition, the method allows to determine the characteristics of a protein such as folding properties, chemical and physical stability, binding constants of protein-protein and protein-ligand interactions as well as to examine the thermodynamics of protein unfolding and kinetics of folding of proteins and peptides.




The core is equipped with an AVIV M400 Spectrophotometer.


The Core provides full training of spectrophotometer and software usage, protocols of start-up experiments, consulting in experimental design, support in data analysis, interpretation and presentation.


For users more detailed information is available on the CD pages.


Raw data of a wavelength spectrum of a helical protein determined by the Core.  Presented with kind permission from Dr. Manevich, Cell and Molecular Pharmaology & Experimental Therapeutics at MUSC.